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The transmission of G-protein-coupled receptors involves only two steps: binding to the receptor protein and activation of G-proteins. True or false?

Respuesta :

Iqta

Answer:

False

Explanation:

G-Protein Coupled Receptors (GPCR):

GPCRs are transmembrane receptors with three components:

  1. Extracellular domain for ligand binding
  2. Seven transmembrane helices
  3. Intracellular G-protein binding domain

Transmission Through GPCRs:

  1. A ligand binds to the extracellular domain of the GPCR.
  2. The GPCR undergoes conformational changes.
  3. This conformational change activates the G-protein by replacing its bound GDP (guanosine diphosphate) with GTP (guanosine triphosphate).
  4. The G-protein then loses its GTP bound alpha subunit which activates the adenylyl cyclase system.

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